The damages of endothelial cells may cause varieties of vascular diseases. In order to protect endothelial cells against damageandimprove functions ofendothelial cells，we can make use of botanical active substances to act on these cells. The paper summarizes the classifications，sources and functions of botanical active substances that have functions of protecting endothelial cells from damages. It also lists the common models of endothelial cell damage，and compares the situation of studies on the protection of botanical active substances to the endothelial cell damages. The paper tries to provide theoretical foundation for the large-scale using of botanical active substances in the future，expecting it to be a trend to use the botanical active substances on the damages of endothelial cells. It aims to prevent and treat vascular diseases.
