卡拉胶多糖的分子修饰:卡拉胶酶和硫酸化酶的研究进展
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

Q946

基金项目:


Molecular Modification of Carrageenan Polysaccharides: Research Progress of Carrageenases and Sulfatase
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    卡拉胶(carrageenan)是一种从海洋红藻细胞壁中提取出来的多糖物质,通过1,3-β-D-吡喃半乳糖和1,4-α-D -吡喃半乳糖交替连接作为基本骨架形成的线性硫酸多糖。研究表明,卡拉胶及其分子修饰后获得的衍生物具有抗肿瘤、抗病毒、抗凝血、增强人体细胞免疫和体液免疫力等多方面生物活性。卡拉胶酶属于糖苷水解酶,通过使β-1,4糖苷键断裂来降解卡拉胶。卡拉胶硫酸酯酶又被称作卡拉胶硫酸化酶,是一种作用于卡拉胶寡糖的硫酸基使之游离出无机硫酸的酶。经研究证实,这两种酶对于卡拉胶多糖的降解具有协同作用。然而由于卡拉胶多糖结构的复杂性,人们对于卡拉胶的降解及分子修饰大多数尚未探索。现如今,随着技术的进步以及卡拉胶多糖生物活性的多样性,卡拉胶多糖的分子修饰引起了相关研究者的持续关注。作者概括了近年来卡拉胶多糖的分子修饰,重点介绍了卡拉胶酶和硫酸化酶的研究进展,进一步阐述了其修饰后的生理活性变化。

    Abstract:

    Carrageenan is a kind of linear sulphated polysaccharide extracted from the cell wall of marine red algae, which is formed by the alternating connection of 1,3-β-D-galactose and 1,4-α-D -galactose as the basic skeleton. Studies have shown that carrageenan and its molecular modified derivatives have many biological activities such as anti-tumor, anti-virus, anti-coagulation, enhancing cellular immunity and humoral immunity. Carrageenase is a glycoside hydrolase that degrades carrageenan by breaking theβ-1,4-glycosidic bond. Carrageenan sulfase, also known as carrageenan sulfase, is an enzyme that acts on the sulfate group of oligo-carrageenan to free inorganic sulfuric acid. These two enzymes have a synergistic effect on the degradation of carrageenan polysaccharides. However, due to the complex structure of carrageenan polysaccharides, the degradation and molecular modification of carrageenan have not been explored in the past. Nowadays, with the introduction of technology and the various biological activities of carrageenan polysaccharides, the molecular modification of carrageenan polysaccharides has attracted the continuous attention of relevant researchers. In this paper, the molecular modification of carrageenan polysaccharides in recent years is reviewed, with emphasis on the research progress of carrageenan and sulfatase. The changes of physiological activity after modification were also described.

    参考文献
    相似文献
    引证文献
引用本文

魏衍尚,宁利敏,姚忠,朱本伟.卡拉胶多糖的分子修饰:卡拉胶酶和硫酸化酶的研究进展[J].食品与生物技术学报,2022,41(10):17-36.

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2022-11-16
  • 出版日期: 2022-10-25

版权所有:《食品与生物技术学报》编辑部

地址:江苏省无锡市蠡湖大道1800号  邮政编码:214122

电话:0510-85913526  电子邮件:xbbjb@jiangnan.edu.cn

技术支持:北京勤云科技发展有限公司

微信公众号二维码

手机版网站二维码