姜黄素新型纳米乳药动学与生物等效性研究
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Q556;R392-33

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Study on Pharmacokinetics and Bioequivalence of Curcumin Novel Nano Emulsion in Rats
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    摘要:

    建立高效液相色谱法(HPLC)测姜黄素新型纳米乳(Curcumin novel nano emulsion,CNNE)中姜黄素(Curcumin,Cur)在大鼠体内的血药浓度,通过比较相同给药计量下Cur和CNNE在大鼠体内的血药浓度考察CNNE的药代动力学行为,并比较二者生物等效性。采用水滴法制备CNNE,灌胃给予CNNE与Cur后,采用HPLC法测定Cur的血药浓度,绘制药物浓度物-时间曲线(AUC),DAS2.1.1软件计算药代参数与生物等效性。CNNE 与Cur的房室模型AUC(0-∞)分别为(3 439.27±180.63) (μg·h)/L、(482.07±42.14) (μg·h)/L,CNNE 与Cur的非房室模型AUC(0-∞)分别为(3 410.20±154.09) (μg·h)/L、(446.66±44.02) (μg·h)/L,CNNE的相对生物利用度为713.44%、763.49%。结果表明,将Cur制备成CNNE后促进了Cur的吸收,CNNE的生物利用度提高了约7倍。CNNE与Cur具有生物不等效性。

    Abstract:

    To build a method that Curcumin(Cur) of Curcumin novel nano emulsion,CNNE) were measured by HPLC,study the pharmacokinetic characteristics of the CNNE,and compare the bioequiavailability of CNNE and Cur. CNNE was prepared by water droplets method,and plasma drug concentrations of different time points were measured by HPLC after oral administration CNNE and Cur. The curve of AUC was drew by excel software,and the main pharmacokinetic parameters and bioequiavailability were calculated by DAS2.1.1 software. The parameters of compartmental model,AUC(0-∞) of CNNE and Cur,were(3 439.27±180.63) (μg·h)/L,(482.07±42.14) (μg·h)/L,and the parameters of compartmental model,AUC(0-∞) of CNNE and Cur,were(3 410.20±154.09) (μg·h)/L,(446.66±44.02) (μg·h)/L. The relative bioavailability of compartmental model and non-compartmental of CNNE are 713.44%,763.49%,respectively. The results show that prepared CNNE promoted absorption of Cur,and the bioavailability of CNNE is about seven times as much as Cur. CNNE and Cur are not bioequivalent.

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雷婷婷,张景勍,张雪,张严方,赵华.姜黄素新型纳米乳药动学与生物等效性研究[J].食品与生物技术学报,2018,37(2):146-152.

LEI Tingting, ZHANG Jingqing, ZHANG Xue, ZHANG Yanfang, ZHAO Hua. Study on Pharmacokinetics and Bioequivalence of Curcumin Novel Nano Emulsion in Rats[J]. Journal of Food Science and Biotechnology,2018,37(2):146-152.

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  • 在线发布日期: 2018-04-03
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