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文章摘要
小麦依赖运动诱发的过敏反应研究进展
Research Progress Of Wheat-Dependent Exercise-Induced Anaphylaxis
投稿时间:2020-08-27  修订日期:2020-10-20
DOI:
中文关键词: 小麦依赖运动诱发的过敏反应  流行病学  发病机制  诊断  治疗
英文关键词: wheat-dependent exercise-induced anaphylaxis (WDEIA), epidemiology, pathogenesis, diagnosis, treatment.
基金项目:国家自然科学基金项目(31601404);南昌大学学科交叉创新基金项目(9166-2706003-YB-20-07)
作者单位E-mail
袁娟丽 南昌大学药学院 yuanjuanli@ncu.edu.cn 
吴双双 南昌大学药学院  
张冉冉 南昌大学药学院  
武涌 南昌大学中德联合研究院江西省微尺度交叉科学重点实验室  
陈红兵 南昌大学中德联合研究院  
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中文摘要:
      小麦依赖运动诱发的过敏反应(WDEIA)是一种罕见的,但可能是严重的由IgE介导的食物过敏。患者可耐受小麦制品的摄入,但当伴随运动、服用非甾体抗炎药、酒精和感染等辅助因素时,肠道通透性增强,可促进小麦过敏原吸收,而出现瘙痒、荨麻疹、血管性水肿、呼吸困难、低血压等过敏反应症状,严重者可致过敏性休克。为避免严重反应,及时准确诊断尤为重要。然而由于对该疾病的认识不足,常常诊断延迟。本文较全面地介绍了WDEIA的流行病学研究、发病机制、临床症状及其诊断和治疗等方面的研究进展,将有助于提高对WDEIA的意识,以便及早诊断,有效防治。
英文摘要:
      Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a rare, but potentially severe IgE-mediated food allergies. Patients can tolerate the intake of wheat products. But when wheat ingestion is accompanied by exercise and other augmenting cofactors such as administration of non steroidal anti-inflammatory drugs, alcohol and infection, allergic symptoms in WDEIA are elicited. Augmenting cofactors might increase the intestinal permeability in patients, facilitate the absorption of allergens from the intestine into blood circulation, induce allergic reactions including pruritus, urticaria, vascular edema, dyspnea, hypotension and even anaphylaxis. To avoid serious reactions, timely and accurate diagnosis is particularly important. However, the?correct?diagnosis?is?often?missed or?delayed?due?to?a?lack?of?knowledge concerning the uncommon?disease. This review focused on the epidemiology, pathogenesis, clinical symptoms, diagnosis and treatment of WDEIA. The rise of WDEIA awareness would be beneficial to early diagnosis and effective prevention and treatment.
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