Abstract:The aim of this study is to optimize the prescription crafts of lanshen Lipid-lowering chewable tablet. Using the single factor experiment to filter the flavoring agents,binders,lubricants and tablet hardness;The effects of different mixtures of five components in lanshen lipid-lowering chewable tablet on smelling,tasting,texture,appearance,chewing and acceptability six indicators of the chewing tablet were studied using mixture design by the design-expert to determine the optimal formula. The results suggested that the optimal Formulation of lanshen Lipid-lowering chewable tablet is extract 32.000%,35.000% mannitol,lactose 26.000%,3.000% Mogrosides,menthol 0.600%,0.400% orange flavor,with 75% ethanol as a binder,2% talc,magnesium stearate 1% as a lubricant,tablet hardness of 60 N. Conclusion:The manufactured lanshen Lipid-lowering chewable tablet has a smooth surface,uniform color,taste good,moderate hardness,indicating that the formulation and process technology which is optimized by this method is stable and reliable.
