大豆皂苷I与II及苷元B对黄曲霉毒素B1和苯并芘突变效应的拮抗
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Protective Activities of Soyasaponin I,II and Soyasapogenol B Against Aflatoxin B1 and Benzo[a] Pyrene-Induced Mutagenicity
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    摘要:

    本研究确认了大豆皂苷I与II及苷元B对黄曲霉毒素B1和苯并芘的抗突变作用。Ames试验中,除了最小剂量时大豆皂苷I与II未能显著抑制移码突变外,3个受试物均明显抑制黄曲霉毒素B1和苯并芘诱发的TA98和TA100回复突变。而且,除了最小剂量时大豆皂苷I与II未能显著抑制苯并芘与DNA的结合外,3个受试物均明显抑制人肝癌(HepG2)及支气管上皮(BEAS-2B)细胞中突变剂与DNA加合物的形成。大体上,苷元B比大豆皂苷I与II更有效地抑制移码与碱基置换突变和加合物的形成。因此,3个食源活性成分不仅抑制基因突变同时也拮抗突变剂诱导的DNA损害。

    Abstract:

    Inhibitory activities of soyasaponin I,II and their aglycone for aflatoxin B1(AFB1) and benzo[a]pyrene(B[a]P)-induced mutagenicity were investigated. In the Ames assay,Salmonella typhimurium strains TA98 and TA100 were selected for frameshift and base substitution mutations,respectively. Three compounds showed remarkable protection against AFB1 and B[a]P-induced mutations,with the exception that at the low concentration of 0.3 mg/plate soyasaponins I and II did not significantly inhibit the frameshift mutation. Three compounds also effectively protected against the formation of AFB1-DNA adduct in HepG2 cells and B[a]P-DNA adduct in BEAS-2B cells,with

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光翠娥,干建平,杨红飞,李志刚.大豆皂苷I与II及苷元B对黄曲霉毒素B1和苯并芘突变效应的拮抗[J].食品与生物技术学报,2017,36(8):814-818.

GUANG Cuie, GAN Jianping, YANG Hongfei, LI Zhigang. Protective Activities of Soyasaponin I,II and Soyasapogenol B Against Aflatoxin B1 and Benzo[a] Pyrene-Induced Mutagenicity[J]. Journal of Food Science and Biotechnology,2017,36(8):814-818.

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  • 在线发布日期: 2017-11-01
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