新鲜和干制龙眼果肉多糖免疫调节活性的分析
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TS 201.4

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Analysis of Immunomodulatory Activity of Polysaccharides
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    摘要:

    为比较新鲜和干制龙眼果肉多糖(LPX3、LPG2)免疫调节活性的差异,采用小鼠肠系膜淋巴结细胞和巨噬细胞模型,分析了多糖对细胞增殖和巨噬细胞吞噬以及NO、IL-6和TNF-α分泌的影响。结果显示,LPX3和LPG2在一定剂量范围内均能显著促进小鼠肠系膜淋巴结细胞和巨噬细胞增殖,促进巨噬细胞吞噬和NO分泌(P<0.05)。在400 μg/mL时,LPX3和LPG2诱导巨噬细胞IL-6的分泌量分别为空白对照组的27.31倍和31.54倍,TNF-α的分泌量分别为空白对照组的17.67倍和18.42倍。LPG2表现出比LPX3更强地促进肠系膜淋巴结细胞和巨噬细胞增殖,激活巨噬细胞的作用。

    Abstract:

    This study aimed to investigate the difference of immunomodulatory activity between polysaccharides from fresh (LPX3) and dried longan pulp (LPG2). The effects of LPX3 and LPG2 on the proliferation of mouse mesenteric lymph node cells and macrophages, phagocytosis and NO, IL-6 and TNF-α secretion of macrophages were analyzed. The results showed that LPX3 and LPG2 significantly promoted the proliferation of mouse mesenteric lymph node cells and macrophages, and promoted the macrophage phagocytosis and NO secretion(P< 0.05). When treated with 400 μg/mL LPX3 or LPG2, the secretion levels of IL-6 were increased to 27.31 times and 31.54 times of the control, respectively, while TNF-α contents were increased to 17.67 times and 18.42 times of the control, respectively. At the same concentration, LPG2 exhibited a stronger effect on promoting the proliferation of mesenteric lymph node cells and macrophages and activating macrophages.

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冯 潮,温亚州,杨宇哲,甘庭圣,杨瑞丽,李 武.新鲜和干制龙眼果肉多糖免疫调节活性的分析[J].食品与生物技术学报,2021,40(6):52-59.

FENG Chao, WEN Yazhou, YANG Yuzhe, GAN Tingsheng, YANG Ruili, LI Wu. Analysis of Immunomodulatory Activity of Polysaccharides[J]. Journal of Food Science and Biotechnology,2021,40(6):52-59.

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  • 在线发布日期: 2021-07-26
  • 出版日期: 2021-06-25
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