过度煎炸油诱发大鼠肝脏损伤及其机理研究

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过度煎炸油诱发大鼠肝脏损伤及其机理研究
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Deep-Frying Oil Induced Liver Injury in Rats and Its Mechanism Studies

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通过采用定量灌胃的方式研究过度煎炸油（DFEO）的摄入对大鼠肝脏损伤的影响及其机理。研究发现：干预6周后，DFEO组肝脏指数显著下降（P<0.05），血清中谷丙转氨酶（ALT）、谷草转氨酶（AST）水平显著升高（P<0.01）。肝组织切片观察发现，DFEO组出现大量脂肪空泡，肝窦扩张，肝细胞界限不清，局部腺体出现炎性细胞浸润。RT-PCR结果表明：连续食用过度煎炸油会导致大鼠肝脏组织Gsta2、Gsta3、Gclc、Gclm基因显著下调（P<0.01）。因此，摄入过度煎炸油会破坏肝细胞正常的组织形态，长期摄入会破坏正常的基因表达，影响正常的生命活动。

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The effects of deep-frying edible oil (DFEO) on liver injury in rats and its mechanism were studied using oralgavage of DFEO with given doses. After 6 weeks of intervention, liver index in the DFEO group decreased significantly(P<0.05), while the serum levels of aspartate transaminase(ALT) and aspartate aminotrans ferase(AST) significantly increased (P<0.01).Meanwhile, observation of tissue sections of liver showed that a large number of fat vacuoles and liver sinusoidal expansion in the DFEO group. However, liver cell boundaries were not clear and inflammatory cell infiltration appearedin local glands. The quantitative real-time PCR results showed that 6 weeks continuous consumption of DFEO would cause significant down-regulation of Gsta2、Gsta3、Gclc、Gclm in rat liver tissues(P<0.01). DFEO will cause serious damage to the liver tissue and destroyliver cell morphology, and its long-term intake will damage the normal gene expression leading tonormal life activities affection.

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张裕涵,王雨扬,商文婷,周中凯.过度煎炸油诱发大鼠肝脏损伤及其机理研究[J].食品与生物技术学报,2020,39(12):100-104.

ZHANG Yuhan, WANG Yuyang, SHANG Wenting, ZHOU Zhongkai. Deep-Frying Oil Induced Liver Injury in Rats and Its Mechanism Studies[J]. Journal of Food Science and Biotechnology,2020,39(12):100-104.

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在线发布日期: 2021-04-06
出版日期: 2020-12-25

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