Abstract:Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a rare but potentially severe IgE-mediated food allergy. The symptoms are not induced by the intake of wheat alone. However, if ingestion of wheat is accompanied by the triggering factors such as exercise, non-steroidal anti-inflammatory drugs, alcohol and infection, allergic symptoms are elicited, including pruritus, urticaria, vascular edema, dyspnea, hypotension and even anaphylaxis. To avoid serious allergic reactions, timely and accurate diagnosis is particularly important. However, diagnosis is often missed or delayed due to the lack of knowledge concerning WDEIA. This review focused on the epidemiology, pathogenesis, clinical symptoms, diagnosis and therapy of WDEIA, aiming to raise the awareness of WDEIA and to improve the early diagnosis and effective prevention and treatment.
