荔枝玫瑰酒延缓小鼠皮肤衰老的研究
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(1. 江南大学 食品学院,江苏 无锡 214122;2. 株洲千金药业股份有限公司,湖南 株洲 412000)

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TS 201.4

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Experimental Study of Lychee Rose Wine on Anti-Skin Aging in Mice
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(1. School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; 2. Qianjin Pharmaceutical Co, Zhuzhou 412000, China)

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    摘要:

    为探究荔枝玫瑰酒对衰老小鼠皮肤的干预作用,选用60只ICR小鼠进行实验分析。将小鼠分为正常组(饲喂含质量分数12%乙醇的饮用水),D-半乳糖处理组(饲喂含质量分数12%乙醇的饮用水),VC对照组(饲喂450 mg/kg(以体质量计)的VC),低、中、高剂量荔枝玫瑰酒组(分别饲喂10、20、40 mL/kg(以体质量计)的荔枝玫瑰酒)。正常组注射生理盐水,其余5组皮下注射D-半乳糖,6周后分析。结果显示,小鼠饲喂高剂量荔枝玫瑰酒可在一定程度上恢复皮肤含水率(质量分数)、羟脯胺酸和胶原蛋白质量分数;皮肤切片结果显示高剂量荔枝玫瑰酒饲喂可改善皮肤状态,使真皮层沉积变厚、胶原纤维含量增加;同时,荔枝玫瑰酒可有效降低衰老小鼠皮肤ROS、MDA质量摩尔浓度以及血浆炎症因子质量浓度(P<0.05);RT-PCR结果显示,荔枝玫瑰酒缓解皮肤衰老的功效可能与调节胶原蛋白合成基因(TGF-β1COl1a1COl3a1NF-κBAP-1MMP-1MMP-8)以及抗氧化相关基因(Nrf2GSK-3βHO-1NQO1)表达水平有关(P<0.05)。因此,适宜剂量荔枝玫瑰酒对小鼠皮肤衰老具有一定的干预作用。

    Abstract:

    The effect of lychee rose wine on the skin of aging mice was investigated. Sixty ICR mice were divided into: Normal group (fed with drinking water containing 12% ethanol), D-galactose group (fed with drinking water containing 12% ethanol), VC control group (fed with 450 mg/kg VC), low, medium and high dose lychee rose wine groups (fed with 10, 20 and 40 mL/kg lychee rose wine, respectively). The normal group was injected with normal saline, and the other five groups were subcutaneously injected with D-galactose, which were analyzed after 6 weeks. The content of skin moisture, hydroxyprolinic acid and collagen could be recovered in mice fed with high dose lychee rose wine. The results of skin section showed that high dose of lychee rose wine could improve the skin condition, thickening the dermis deposition and increasing the collagen fiber content. Meanwhile, lychee rose wine could effectively reduce the contents of ROS and MDA in skin and the levels of inflammatory factors in plasma of aging mice (P<0.05). RT-PCR results showed that the effect of lychee rose wine on skin aging might be related to the regulation of expression levels of collagen-synthesizing genes (TGF-β1, COl1a1, COl3a1, NF-κB, AP-1, MMP-1, MMP-8) and antioxidant related genes (Nrf2, GSK-3β, HO-1, NQO1) (P<0.05). The appropriate dosage of lychee rose wine has certain intervention effect on the skin aging of mice.

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徐 莹,李晓娟,孟 君,张 凯,唐 雪.荔枝玫瑰酒延缓小鼠皮肤衰老的研究[J].食品与生物技术学报,2022,41(4).

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  • 在线发布日期: 2022-04-29
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