Abstract:The effect of lychee rose wine on the skin of aging mice was investigated. Sixty ICR mice were divided into: Normal group (fed with drinking water containing 12% ethanol), D-galactose group (fed with drinking water containing 12% ethanol), VC control group (fed with 450 mg/kg VC), low, medium and high dose lychee rose wine groups (fed with 10, 20 and 40 mL/kg lychee rose wine, respectively). The normal group was injected with normal saline, and the other five groups were subcutaneously injected with D-galactose, which were analyzed after 6 weeks. The content of skin moisture, hydroxyprolinic acid and collagen could be recovered in mice fed with high dose lychee rose wine. The results of skin section showed that high dose of lychee rose wine could improve the skin condition, thickening the dermis deposition and increasing the collagen fiber content. Meanwhile, lychee rose wine could effectively reduce the contents of ROS and MDA in skin and the levels of inflammatory factors in plasma of aging mice (P<0.05). RT-PCR results showed that the effect of lychee rose wine on skin aging might be related to the regulation of expression levels of collagen-synthesizing genes (TGF-β1, COl1a1, COl3a1, NF-κB, AP-1, MMP-1, MMP-8) and antioxidant related genes (Nrf2, GSK-3β, HO-1, NQO1) (P<0.05). The appropriate dosage of lychee rose wine has certain intervention effect on the skin aging of mice.
