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产不同细菌素的格氏乳杆菌对小鼠肠道微生态的影响
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TS 201.3

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国家自然科学基金创新研究群体项目（32021005）


Effect of Lactobacillus gasseri with Different Bacteriocins Production on the Intestinal Micro-Ecology in Mice
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    摘要:

    目前已发现格氏乳杆菌（Lactobacillus gasseri，L. gasseri）产生的多种细菌素对多种致病菌具有抑制作用，但有关细菌素对格氏乳杆菌和宿主肠道微生态之间关系的研究较少。为探究产不同细菌素的格氏乳杆菌及其对小鼠肠道微生态的影响，作者通过细菌素操纵子预测、抑菌试验以及液相色谱－质谱联用法证明了格氏乳杆菌FNMGHLBE6L1、FNMGHLBE20L5、FHNFQ16L5可产不同细菌素，之后通过动物试验探究不同格氏乳杆菌对小鼠肠道微生态的影响。结果表明，3株格氏乳杆菌均对小鼠肠道菌群的多样性及菌群结构产生了显著影响；且格氏乳杆菌显著降低了小鼠结肠中白介素-1β的水平。综上，产不同细菌素的格氏乳杆菌可对宿主肠道菌群产生显著影响，且菌株间的差异与所产细菌素存在相关性。该研究为探究产不同细菌素的格氏乳杆菌与肠道菌群之间的关联提供了依据。

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    It has been reported that Lactobacillus gasseri produces a variety of bacteriocins that inhibit a few kinds of food pathogenic bacteria, but there are few researches on how bacteriocins affect the interaction between Lactobacillus gasseri and the intestinal microecology. This study utilized the in silico prediction of bacteriocin operon, antibacterial experiment with six strains of food-borne pathogenic bacteria as indicators and liquid chromatograph mass-spectrometer/mass spectrometer analysis to prove that Lactobacillus gasseri FNMGHLBE6L1, FNMGHLBE20L5 and FHNFQ16L5 produced different bacteriocins. Through the animal experiments, the effects of three bacteriocin-producing Lactobacillus gasseri strains on the intestinal microecology of the mice were investigated. The diversity and profile of the gut microbiota were dramatically influenced by all three strains of Lactobacillus gasseri, and the level of colonic interleukin-1β was also significantly decreased. In summary, the gut microbiota was significantly affected by bacteriocin-producing Lactobacillus gasseri, and the variations in effects among strains were associated with their bacteriocin production. This study could serve as a guide for future research on the relationship between various bacteriocin-producing Lactobacillus gasseri and the gut microbiota.

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胡静怡,杨 波,赵建新,张 灏,陈 卫.产不同细菌素的格氏乳杆菌对小鼠肠道微生态的影响[J].食品与生物技术学报,2024,43(6):1-10.

HU Jing-yi, YANG Bo, ZHAO Jian-xin, ZHANG Hao, CHEN Wei. Effect of Lactobacillus gasseri with Different Bacteriocins Production on the Intestinal Micro-Ecology in Mice[J]. Journal of Food Science and Biotechnology,2024,43(6):1-10.

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  • 在线发布日期: 2024-08-16
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