藤茶多酚对小鼠衰老过程中骨质代谢及肠道菌群的影响
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R 151.3

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国家“十四五”重点研发计划项目(2022YFF1100203);江苏省自然科学基金项目(BE2021623);南京医科大学无锡医学中心队列与临床研究项目(WMCC202311)


Effects of Ampelopsis Grossedentata Polyphenols on Bone Metabolism and Gut Microbiota in Aging Mice
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    摘要:

    肠道菌群对于宿主健康起着至关重要的作用,与衰老过程中骨质代谢紊乱息息相关。作者旨在研究以长寿特性而闻名的巴马藤茶对小鼠衰老进程中骨质代谢的影响,以评估藤茶多酚改善衰老小鼠肠道菌群结构的潜力。结果表明,藤茶多酚可以上调小鼠肝脏中的超氧化物歧化酶、谷胱甘肽和总抗氧化力水平,下调丙二醛水平。同时,藤茶多酚能够通过改善小鼠衰老过程中的骨质代谢,上调Osterix基因的表达,降低Acp5的表达,从而促进骨形成、减少骨吸收。此外,藤茶多酚可以调节衰老小鼠的肠道菌群组成,促进粪便中乙酸、丙酸和丁酸的产生。总之,藤茶多酚可以作为一种益生元,减少衰老过程中的骨质流失并调节肠道菌群,从而达到延缓衰老的目的。

    Abstract:

    Gut microbiota plays a crucial role in host health and is closely related to bone metabolism disorders during aging. The author aimed to investigate the effects of Bama Ampelopsis Grossedentata (AG), known for its longevity properties, on bone metabolism in aging mice, to assess the potential of AG polyphenols to improve gut microbiota composition in aging mice. The results showed that polyphenols could up-regulate the levels of superoxide dismutase, glutathione, and total antioxidant power, while down-regulate the content of malondialdehyde in the liver of mice. Simultaneously, AG polyphenols could promote bone formation and reduce bone resorption by improving the bone metabolism in aging mice, up-regulating the expression of Osterix gene, and reducing the expression of Acp5. Furthermore, AG polyphenols could modulate the gut microbiota composition in aging mice and promote the production of acetic acid, propionic acid, and butyric acid in feces. In conclusion, AG polyphenols have potential as a future prebiotic to mitigate age-related bone loss and regulate gut microbiota, thereby achieving the goal of delaying aging.

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潘佳妮,洪侃,于雷雷,张程程,张青松,翟齐啸,田丰伟.藤茶多酚对小鼠衰老过程中骨质代谢及肠道菌群的影响[J].食品与生物技术学报,2024,43(4):46-53.

PAN Jia-ni, HONG Kan, YU Lei-lei, ZHANG Cheng-cheng, ZHANG Qing-song, ZHAI Qi-xiao, TIAN Feng-wei. Effects of Ampelopsis Grossedentata Polyphenols on Bone Metabolism and Gut Microbiota in Aging Mice[J]. Journal of Food Science and Biotechnology,2024,43(4):46-53.

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  • 在线发布日期: 2024-05-27
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