益生菌对食源性脂质代谢紊乱相关疾病的缓解作用及机制研究进展
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国家自然科学基金青年基金项目(32302045);江苏省自然科学基金青年基金项目(BK20220333)。


Research Progress on the Alleviating Effects and Mechanisms of Probiotics on Diet-Induced Lipid Metabolism Disorders
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    摘要:

    食源性脂质代谢紊乱会引发多种疾病,已经逐渐成为全球性的公共卫生问题。越来越多的研究表明,益生菌具有调节脂质代谢的功效,因此挖掘具有预防和改善食源性脂质代谢紊乱相关疾病潜力的益生菌具有广阔的应用前景。作者概述了益生菌对食源性脂质代谢紊乱引起的肠道菌群失衡、炎症性肠病和免疫力下降的缓解作用,从肠-肝轴循环、关键代谢物质和菌株自身特性等角度阐述了益生菌对食源性脂质代谢的调控机制,为开发具有调节食源性脂质代谢紊乱功效的益生菌提供参考。

    Abstract:

    Diet-induced lipid metabolism disorders are associated with a variety of diseases and have gradually become a global public health concern. An increasing number of studies have demonstrated that probiotics exhibit regulatory effects on lipid metabolism, highlighting their potential in preventing and mitigating diseases related to such disorders. The author provides a comprehensive overview of the alleviating effects of probiotics on gut microbiota dysbiosis, inflammatory bowel disease, and decreased immunity caused by diet-induced lipid metabolism disorders. The regulatory mechanisms of probiotics on lipid metabolism is elaborated from some perspectives including the gut-liver axis, key metabolic substances, and strain-specific characteristics. This review offers insights and references for developing probiotics with efficacy in modulating diet-induced lipid metabolism disorders.

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顾敏雯,刘皓文,祝晨昕,丁思琪,姚源玥,崔 洁,李文慧,张 健,姜金池,胡永红.益生菌对食源性脂质代谢紊乱相关疾病的缓解作用及机制研究进展[J].食品与生物技术学报,2024,43(10):21-31.

GU Min-wen, LIU Hao-wen, ZHU Chen-xin, DING Si-qi, YAO Yuan-yue, CUI Jie, LI Wen-hui, ZHANG Jian, JIANG Jin-chi, HU Yong-hong. Research Progress on the Alleviating Effects and Mechanisms of Probiotics on Diet-Induced Lipid Metabolism Disorders[J]. Journal of Food Science and Biotechnology,2024,43(10):21-31.

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  • 在线发布日期: 2025-01-16
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