食源性生物活性肽的抗癌活性及应用研究进展
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1浙江工商大学食品与生物工程学院,浙江 杭州 310018;2浙江省微生物重点实验室,浙江 杭州 310018

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李延华(1979—),女,博士,副教授,硕士研究生导师,主要从事微生物发酵、食品加工研究。E-mail:liyanhua607@163.com

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浙江省科技厅重点研发项目(2019C02091)。


Research Progress in Anti-cancer Activity and Application of Food-derived Bioactive Peptides
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1School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China;2Key Laboratory for Food Microbial Technology of Zhejiang Province, Hangzhou 310018, China

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    摘要:

    由于患癌人数日益增多且传统药物对耐药癌细胞的治疗效果下降,医疗领域对于新型抗癌药物的需求上升。癌细胞因为具有特殊的代谢方式,会形成不同于正常组织的微环境,并发展出免疫逃逸能力。部分生物活性肽(bioactive peptides,BAPs)具有良好的抗癌活性,被称为抗癌肽(anti-cancer peptides,ACPs)。ACPs来源广泛,具有潜在的医疗应用前景。其通过破坏癌细胞膜、调节癌细胞生长与增殖等途径表现出抗癌活性。同时,ACPs由于相对分子质量小且结构暴露,单独存在时难以在体内的复杂环境中保持稳定性,其效用不可避免会损失,因此开发高效抗癌产品具有一定困难,需要进行一定程度的联用或保护。作者介绍了ACPs的食源性来源,阐释了ACPs的抗癌活性及分子机制,结合ACPs可以直接攻击或者间接阻碍癌细胞的作用效果,总结了ACPs在新型抗癌药物基质中的使用方式和开发潜力,为食源性ACPs在医疗领域的应用提供参考。

    Abstract:

    Due to the increasing number of cancer patients and the decreasing effectiveness of conventional drugs on drug-resistant cancer cells, there is a growing demand for new anti-cancer drugs in the medical field. Some bioactive peptides (BAPs) have good anti-cancer activity and are known as anti-cancer peptides (ACPs). They are widely available and have potential medical application prospects. Cancer cells, due to their unique metabolic pathways, create a microenvironment different from normal tissue and develop immune escape abilities. ACPs exhibit anti-cancer activity by disrupting cancer cell membranes, regulating cancer cell growth and proliferation, and other pathways. However, due to their small molecular weight and exposed structure, ACPs are difficult to maintain stability in the complex environment of the body, and thus their effectiveness is inevitably lost, which poses certain difficulties for developing efficient products and requires a certain degree of combination or protection. The author introduces the food sources of ACPs and explains the anti-cancer activity and molecular mechanisms of ACPs. Considering the effectiveness of ACPs in directly attacking or indirectly hindering cancer cells, the author summarizes the usage and development potential of ACPs in new anti-cancer drug matrices, providing a reference for the application of food-derived ACPs in the medical field.

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舒蓝婕,李延华,郭金琪,马敬敬,陈雨萌.食源性生物活性肽的抗癌活性及应用研究进展[J].食品与生物技术学报,2026,45(4):1-8.

SHU Lanjie, LI Yanhua, GUO Jinqi, MA Jingjing, CHEN Yumeng. Research Progress in Anti-cancer Activity and Application of Food-derived Bioactive Peptides[J]. Journal of Food Science and Biotechnology,2026,45(4):1-8.

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  • 收稿日期:2025-06-30
  • 最后修改日期:2025-09-21
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  • 在线发布日期: 2026-08-08
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