小檗碱和人参皂苷Rb1合用对脂肪细胞炎症因子表达和炎症信号通路的影响

doi:10.3969/j.issn.1673-1689.2014.06.006

首页 > 过刊浏览>2014年第33卷第6期 >597-603. DOI:10.3969/j.issn.1673-1689.2014.06.006

小檗碱和人参皂苷Rb1合用对脂肪细胞炎症因子表达和炎症信号通路的影响
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                        10.3969/j.issn.1673-1689.2014.06.006
                    
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Effect of Combination of Berberine and Ginsenosides Rb1 on Inflammatory Adipocytokines and Inflammatory Signaling Pathways in Adipocytes

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将诱导分化成熟的3T3-L1脂肪细胞分别在基础状态和肿瘤坏死因子（TNF-α）作用下给予小檗碱、人参皂苷Rb1、小檗碱和人参皂苷Rb1合用处理后，以罗格列酮为阳性对照，观察药物对脂肪细胞炎症因子表达和炎症信号通路的作用。结果表明，无论在基础状态下还是在TNF-α作用下，小檗碱对脂肪炎症因子的表达和炎症信号通路均具有明显的抑制作用；而人参皂苷Rb1的作用则不明显；两者合用后并未显示出协同或增效作用。

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The differentiated 3T3-L1 adipocytes were stimulated with/without tumor necrosis factor-α(TNF-α), then treated with berberine, ginsenosides Rb1, and both berberine and ginsenosides Rb1. The expression of TNF-α, interleukin-6(IL-6), resistin, adiponectin, and monocyte chemoattractant protein-1(MCP-1) were detected with real time quantitative PCR. The phosphorylation of IKK-beta and JNK were examined with western blotting. The results indicated that berberine can inhibit the expressions of inflammatory factors and inflammatory signaling transduction in adipocytes, but ginsenoside Rb1 doesn't produce obvious inhibitory effects, while rosiglitazone used as positive control drug. When combined with ginsenoside Rb1, the inhibitory effects to 3T3-L1 adipocytes of berberine are weakened, either with or without the stimulation of TNF-α.

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张红霞,赵娟,于希忠,郭超,潘扬,尚文斌.小檗碱和人参皂苷Rb1合用对脂肪细胞炎症因子表达和炎症信号通路的影响[J].食品与生物技术学报,2014,33(6):597-603.

ZHANG Hongxia, ZHAO Juan, YU Xizhong, GUO Chao, PAN Yang, SHANG Wenbin. Effect of Combination of Berberine and Ginsenosides Rb1 on Inflammatory Adipocytokines and Inflammatory Signaling Pathways in Adipocytes[J]. Journal of Food Science and Biotechnology,2014,33(6):597-603.

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在线发布日期: 2014-10-19
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