Abstract:Extraction of Monascus pigments in mycelia by ultrasonic-assisted technology, on the basis of single factor experiments, using response surface method optimizes the extraction of red pigment process parameters. A quadratic regression model was established, and the optimum extraction conditions were obtained. The results showed that ethanol concentration, solid-liquid ratio, ultrasonic wave power of these three factors on the extraction of red pigment had a significant influence, ethanol concentration 76.30%, solid-liquid ratio 34.44∶1, ultrasonic wave power 304.84 W. Under the optimum conditions, the red pigment concentration of the extract reached the maximum 5 679.4 U/g, the yellow pigment was as high as 4 633 U/g. With the national standard compared to red pigment extraction, the extraction rate increased by 6.5% and 8.9% .