Abstract:The central composite design and response surface methodology were applied to optimize the preparation technology of naringenin-β-cyclodextrin inclusion complexes. The inclusion ratio and the yield of inclusion complexes were studied as independent variables, using several dependent variables such as stirring, the mass ratio of NAR-β-CD, inclusion time, and inclusion temperature. The results were fitted by linear equations and second-order polynomial equation based on the central composite design and response surface method. The optimal inclusion process was predicted according to formulation and further verified by experiments. The cumulative dissolution rates of the NAR-β-CD inclusion complexes and the NAR were comparatively studied. The optimal condition for the preparation of NAR-β-CD inclusion complexes was achieved with a ratio of 5∶1(β-CD∶NAR), inclusion time of 1.412 h，and inclusion temperature at 48.11 ℃,where the bias for the prediction value and theoretical value of the inclusion ratio and the yield of inclusion complexes were 1.43% and 1.99%, while the cumulative dissolution rate of NAR and NAR-β-CD inclusion complexes were 37.15% and 83.24%, respectively.
