Abstract:The objective of this study was to explore the protective effects of Mesona blumes extracts on carbon tetrachloride induced liver injury in mice.Seventy male mice were randomly divided into seven groups(model control group,positive control group,ethanol extracts group,low dosage,middle dosage and high dosage of water extracts groups).The mice in the above groups were fed for 30 days.ALT,AST,Alb,TG in serum and SOD,MDA,GSH,GSH-PX in liver tissue were measured and compared.It was found that water extracts of Mesona blumes significantly increased the values of AST(P<0.01),ALT(P<0.05),Alb(P<0.05),TG(P<0.01) in serum and MDA(P<0.01),GSH,GSH-PX(P<0.01) in liver tissue,respectively.However,no obvious difference was detected at the SOD activities(P>0.05).Also,There is no remarkable difference between different dosage of water extracts groups and bifendate pills groups(P>0.05).Ethanol extracts of Mesona blumes wasn’t found to effectively decreased liver damage in terms of above mentioned biochemical parameters compare to model control group.Those results indicated that water extracts of Mesona blumes plays a significant protective role on liver injury which induced by carbon tetrachloride.
