Anti-Oxidant and Hepato-Protective Effect of Spirulina platensis in Vivo

doi:10.3969/j.issn.1673-1689.2009.06.011

Home > Archive>Volume 28, Issue 6, 2009 >777-780. DOI:10.3969/j.issn.1673-1689.2009.06.011

Anti-Oxidant and Hepato-Protective Effect of Spirulina platensis in Vivo
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                        10.3969/j.issn.1673-1689.2009.06.011
                    
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Abstract:

In this study,the anti-oxidant and hepato-protective effect of Spirulina plantensis on D-galactosamine(D-GalN) induced liver injury in mice were investigated.ICR mice were fed a control diet(AIN-93G) or a diet contaning 5% Spirulina plantensis for one week and on the last day of feeding the mice were treated with D-GalN(300 mg/kg body weight,i.p.).The serum glutamate oxaloacetate transaminase(GOT) and glutamate pyruvate transaminase(GPT) activities,hepatic malondialdehyde(MDA),reduced glutathione(GSH) and vitamin C levels were determined 6 h later by kits or by the method of TBARS,DTNB or DNPH,respectively.It was found that D-GalN induced increased in serum GOT,GPT and hepatic MDA level,but decreased in the GSH and vitamin C content.The results presented here demonstrated that Spirulina plantensis exhibited a significant antioxidant and protective on the D-GalN induced hepatotoxicity.

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LU Jun, REN Di-feng, WANG Jian-zhong, LU Yong, Egashira Yukari. Anti-Oxidant and Hepato-Protective Effect of Spirulina platensis in Vivo[J]. Journal of Food Science and Biotechnology,2009,28(6):777-780.

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Online: June 16,2014
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