Protective Effects on Mitochondria and Anti-Aging Activity of Aqueous Extract of Forsythia suspensa Leavies

doi:10.3969/j.issn.1673-1689.2009.06.013

Home > Archive>Volume 28, Issue 6, 2009 >840-844. DOI:10.3969/j.issn.1673-1689.2009.06.013

Protective Effects on Mitochondria and Anti-Aging Activity of Aqueous Extract of Forsythia suspensa Leavies
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                        10.3969/j.issn.1673-1689.2009.06.013
                    
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The objective of this study was to investigate protective effects and mechanism of Forsythia suspensa leavies(FLA) aqueous extract on mitochondrial injury induced by free radicals.Process: The neck back of mice were injected subcutaneously with D-galactose to induce aging model at a dose of 100 mg/(kg·d)for 7 weeks and a set of interesting results were achieved: FLA efficient inhibit mitochondrial injury and swelling induced by Fe2+-L-Cys in a concentration-dependent manner and also had significant O2˙-scavenging effect.Moreover,the activities of CAT,SOD,GSH-Px and anti-hydroxyl radical in mice liver homogenate were increased significantly by FLA.FLA protects mitochondria by scavenging reactive oxygen species,and increasing the activities of antioxidases.The results present here strong suggested that FLA is a potential drug for antioxidant and anti-aging.

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LI Xing-tai, CHEN Rui, GAO Ming-bo. Protective Effects on Mitochondria and Anti-Aging Activity of Aqueous Extract of Forsythia suspensa Leavies[J]. Journal of Food Science and Biotechnology,2009,28(6):840-844.

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Online: June 16,2014
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