Abstract:To investigate the effect and mechanism of lycopene nanodispersion on tumor growth,lycopene nanodispersion was prepared by the emulsification-evaporation process (the ultrasonic emulsification).The antitumor effect,antioxidant activity and anti-proliferation activity in vivo were studied with the model of mice transplanted with hepatoma H22.The results showed that lycopene nanodispersion was obtained by the process.When mice transplanted with hepatoma H22 were treated with 1.95 mg/kg and 3.9 mg/kg lycopene nanodispersion for 10 days,the tumor growth inhibitory rate were 32.37% and 54.34% respectively.The intake of lycopene nanodispersion led to the increase of glutathione peroxidase (GSH-Px) activity,and the reduction of the mice serum malondialdehyde (MDA) content.It also led to the increase of total antioxidant capability (T-AOC) and superoxide dismutase (SOD) activity,but decrease the content of MDA and hydrogen peroxide (H2O2 ) of liver of mice.It also could inhibit the expression of proliferating cell nuclear antigen (PCNA) in tumor tissue.These results suggested that lycopene nanodispersion can significantly suppress the growth of hepatoma H22 in vivo.The increases of anti-oxidation activity and anti-proliferation activity may contribute to the antitumor mechanism.
