Study on the Production of Antitumor Metabolite by Myxobacteria AHB 103-1

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Study on the Production of Antitumor Metabolite by Myxobacteria AHB 103-1
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This study investigated the effect of medium compositions and the environmental conditions on the production of antitumor metabolite and listed as follows: carbon source,corn starch,nitrogen source,yeast extract;the ratio of carbon and nitrogen,12:6;If 5 mg/L Gly,Glu,Ala,10 mg/L Try,Tyr,1.0 mg/L LiSO4、MnCl2、Na2MoO4、NaH2PO4 were supplemented to the culture broth,the yield of antitumor secondary metabolite would be significant improved.The optimum fermentation conditions were as follows: fermentation term,7 d;initiative pH 7.4;fermentation temperature,30 ℃;seed culture term,4 d;the volume of culture liquid contained in 500 mL conical tank,125 mL;rotor speed,150 r/min.

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XU Feng, TAO Wen-yi. Study on the Production of Antitumor Metabolite by Myxobacteria AHB 103-1[J]. Journal of Food Science and Biotechnology,2010,29(4):589-594.

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Online: June 17,2014
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