Abstract:The research aimed to study the anti-tumor effect of polysaccharides from Inonotus obliquus(IOP)on tumor cell proliferation in vitro and on tumor-bearing nude mice in vivo.The effect of polysaccharides from Inonotus obliquus(IOP)on tumor Jurkat and Daudi cell proliferation was measured by MTT assay.The model of jurkat tumor-bearing nude was established.The anti-tumor effect of IOP on tumor-bearing nude mice in vivo was studied.The result showed that IOP could kill jurkat and daudi tumor cell directly in vitro.The highest inhibition rate was 62.29% and 66.42%,respectively,which showed an excellent dose-response relation.Similarly,IOP also shown the obvious anti-tumor activities in vivo.The inhibition rate at low and high dose were 43.52% and 57.48%,respectively.IOP increased obviously the spleen index.It was concluded that IOP had obvious anti-tumor activities and improved immunological function.
