Apoptosis of Human Umbilical Vein Endothelial Cells Induced by Trans C18∶1

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Apoptosis of Human Umbilical Vein Endothelial Cells Induced by Trans C18∶1
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The target of this study is to exoplore the apoptotic mechanism of endothelial cells through detecting relevanting apoptosis index.For this,EC were cultured with trans C18∶1 at different concentrations,then the morphological changes of endothelial cells were observed through giemsa staining.The apoptotic cells were detected by flow cytometry.The activity of caspase-3 was detected by spectrophotography after endothelial cells treated with trans C18∶1.The cell viability was measured by MTT after endothelial cells cultured with trans C18∶1 and caspase inhibitor for 24～48 h.Results: The number of apoptotic cells raised and endothelial cells displayed classical apoptotic morphology after endothelial cells cultured with trans C18∶1.The activity of caspase-3 ascended and the caspase inhibitor could protect endothelial cells from trans C18∶1.

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QIU Bin, LIU Rong, DENG Ze-yuan, FAN Ya-wei, LI Jing, HU Jiang-ning, LI Yu. Apoptosis of Human Umbilical Vein Endothelial Cells Induced by Trans C18∶1[J]. Journal of Food Science and Biotechnology,2011,30(4):588-591.

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Online: June 17,2014
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