Preliminary Study on the Transport of Pinctada Martensii High Fischer Ratio Oligopeptides Across a Caco-2 monolayer

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Preliminary Study on the Transport of Pinctada Martensii High Fischer Ratio Oligopeptides Across a Caco-2 monolayer
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The transport of PHFP across a Caco-2 monolayer was studied in this manuscript.The results showed that the absorption quantity of PHFP increased either AP→BL or BL→AP.After adding the inhibitor of P-glycoprotein verapamil,the permeability coefficient(AP→BL) increased from 6.83 ×10-7 cm/min to 8.16 ×10-7 cm/min,and the permeability coefficient(BL→AP) decreased from 8.84×10-7 cm/min to 2.20×10-7cm/min.This results indicated that there existed an efflux system and parts of PHFP were metabolized by metabolic enzymes of cells during the transport,and the metabolism yield of PHFP decreased after adding verapamil.

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ZHENG Hui-na, ZHANG Chao-hua, JI Hong-wu, QIN Xiao-ming, HUANG Lai-zhen. Preliminary Study on the Transport of Pinctada Martensii High Fischer Ratio Oligopeptides Across a Caco-2 monolayer[J]. Journal of Food Science and Biotechnology,2011,30(4):613-617.

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