Inhibitory Effect of Chinese Herbs Extracts on Human Dermal Fibroblasts Apoptosis Induced by H2O2

doi:10.3969/j.issn.1673-1689.2012.09.003

Home > Archive>Volume 31, Issue 9, 2012 >912-917. DOI:10.3969/j.issn.1673-1689.2012.09.003

Inhibitory Effect of Chinese Herbs Extracts on Human Dermal Fibroblasts Apoptosis Induced by H2O2
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                        10.3969/j.issn.1673-1689.2012.09.003
                    
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This study aims to establish the cell injury and apoptosis model of human dermal fibroblasts induced by hydrogen peroxide in vitro and investigate the protective effects of several Chinese herbs on hydrogen peroxide-induced oxidative stress injury.The viability of human dermal fibroblasts was measured with MTT chromatometry,then the morphological changes of cells were observed through Hoechst 33342 staining and the apoptotic cells were detected by TUNEL assay.The results showed that normal human dermal fibroblasts were damaged by hydrogen peroxide at a appropriate concentration(0.8 mmol/l) for 6 h.The results also indicated that Chinese herbs increased obviously the cell viability and decreased the apoptosis rate.It was concluded that Chinese herbs could protect human dermal fibroblasts from hydrogen peroxide-induced oxidative stress injury.

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FENG Bing, ZHAO Ya, FANG Yun, WEI Shao-min. Inhibitory Effect of Chinese Herbs Extracts on Human Dermal Fibroblasts Apoptosis Induced by H2O2[J]. Journal of Food Science and Biotechnology,2012,31(9):912-917.

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