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Home > Archive>Volume 33, Issue 12, 2014 >1294-1299. DOI:10.3969/j.issn.1673-1689.2014.12.010
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Study of Temperature Sensitive Nano Drug Delivery System Based on Hyaluronic Acid
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    Abstract:

    An amphiphilic material(HA-F127) was prepared by conjugating hyaluronic acid(HA) and pluronic(F127) via "Click" chemistry. The chemical structure of HA-F127 was identified through 1H NMR spectrum, and the degree of substitution was 13%. HA-F127 could self-assemble into nanoparticles in aqueous solution and load model anticancer drug doxorubicin. In vitro drug release assay showed the nanoparticle behaved temperature sensitive drug release profile. Since hyaluronic acid could recognize CD44 receptor, which over-expressed on cancer cell surface, the nanoparticles could targetedly deliver drug into cancer cells and obtain promoted therapeutic effect.

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CHEN Jingxiao, CAO Lujuan, MENG Zhaomin, LIU Bozheng, CHEN Jinghua. Study of Temperature Sensitive Nano Drug Delivery System Based on Hyaluronic Acid[J]. Journal of Food Science and Biotechnology,2014,33(12):1294-1299.

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  • Online: December 19,2014
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