Preparation of Heparin/Chitosan Microcapsule for Anticoagulation Study

doi:10.3969/j.issn.1673-1689.2015.03.011

Home > Archive>Volume 34, Issue 3, 2015 >295-301. DOI:10.3969/j.issn.1673-1689.2015.03.011

Preparation of Heparin/Chitosan Microcapsule for Anticoagulation Study
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                        10.3969/j.issn.1673-1689.2015.03.011
                    
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Heparin/chitosan(HEP/CHI)5 microcapsules for anticoagulation were prepared by Layer-by-layer(LbL) technique. The stability of(HEP/CHI)5 microcapsules under pH 5.0 and 7.4,simulated gastric and intestinal juices conditions was studied respectively,APTT anticoagulant time and cytotoxicity of microcapsules against endothelial cells were estimated. Results indicated that(HEP/CHI)5 microcapsules were of spherical structure and stable in different simulated physiological milieus;they could behave favorable anticoagulant efficacy with no significant cytotoxicity. Thus,(HEP/CHI)5 microcapsules were promising for clinical heparin administration as a novel oral dosage form.

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LIANG Yan, SONG Jiahong, CHEN Jingxiao, CHEN Jinghua. Preparation of Heparin/Chitosan Microcapsule for Anticoagulation Study[J]. Journal of Food Science and Biotechnology,2015,34(3):295-301.

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Online: April 16,2015
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