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Home > Archive>Volume 36, Issue 4, 2017 >371-375. DOI:10.3969/j.issn.1673-1689.2017.04.006
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Protective Effects of Lepidium Meyenii（Maca） Aqueous Extract on Benign Prostatic Hyperplasia in Mice
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    Abstract:

    The main substance in Maca aqueous extract responsible for the inhibition of benign prostatic hyperplasia（BPH） in mice was investigated in this study and the mechanism was discussed. Fifty male ICR mice were randomly divided into five groups：the control group，the BPH model group，the finasteride group，the Maca extract group treated with 60 mg/kg Maca（containing 1.44 mg/kg benzyl glucosinolate） and the benzyl glucosinolate group with a dose of 1.44 mg/kg. BHP was induced in all mice by subcutaneous injection of testosterone propionate（TP，5.0 mg/kg） with the control group excepted. The inhibitory effects on BPH of Maca extract and benzyl glucosinolate were evaluated using the prostate wet weight，the prostatic index（PI），testosterone（T），dihydrotestosterone（DHT），estradiol（E2），the value of T/E2，the prostatic acid phospatase（PAP） in serum and histopathology examination. Comparing with the BPH model group，the Maca extract group and benzyl glucosinolate group significantly decreased the prostate wet weight and PI（P＜0.01），as well as the values of T，DHT and T/E2 in serum（P＜0.05 or P＜0.01）. A great reduction of BPH was observed with the prostate glandular hyperplasia reduced or disappeared. The similar histological effects were achieved for the Maca group and benzyl glucosinolate group. The results confirmed an effective inhibition of BPH in mice by the Maca aqueous extract and benzyl glucosinolate which was suggested as the main bioactive component in Maca extract.

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ZOU Ying, ZHANG Lianfu. Protective Effects of Lepidium Meyenii（Maca） Aqueous Extract on Benign Prostatic Hyperplasia in Mice[J]. Journal of Food Science and Biotechnology,2017,36(4):371-375.

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