Comparative Pharmacokinetic Study of BCNE and CCNE

doi:10.3969/j.issn.1673-1689.2017.04.015

Home > Archive>Volume 36, Issue 4, 2017 >420-424. DOI:10.3969/j.issn.1673-1689.2017.04.015

Comparative Pharmacokinetic Study of BCNE and CCNE
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                        10.3969/j.issn.1673-1689.2017.04.015
                    
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Bisdemethoxycurcumin nanoemulsion（BCNE） and curcumin nanoemulsion（CCNE） were prepared and their pharmacokinetics was evaluated. Plasma samples were collected from the retinal venous plexus of SD rats after oral administration of BCNE and CCNE. The concentration of BC in plasma was determined by HPLC. The pharmacokinetic parameters of BCNE and CCNE were calculated with DAS2.1.1 pharmacokinetic program. Tmax of BCNE and CCNE were 1.50 h and 1.00 h，while Cmax were 85.87±2.53 μg/L and 85.60±2.29 μg/L. AUC0~72 h for BCNE and CCNE were 788.23±52.04 μg/L·h and 1345.50±64.88 μg/L·h，respectively. The oral bioavailability of CCNE exhibited better performance than that of BCNE.

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CHEN Jing, YANG Mei, ZHANG Jingqing, JIANG Xinhui, HU Xueyuan. Comparative Pharmacokinetic Study of BCNE and CCNE[J]. Journal of Food Science and Biotechnology,2017,36(4):420-424.

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