Study on Pharmacokinetics and Bioequivalence of Curcumin Novel Nano Emulsion in Rats

doi:10.3969/j.issn.1673-1689.2018.02.005

Home > Archive>Volume 37, Issue 2, 2018 >146-152. DOI:10.3969/j.issn.1673-1689.2018.02.005

Study on Pharmacokinetics and Bioequivalence of Curcumin Novel Nano Emulsion in Rats
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                        10.3969/j.issn.1673-1689.2018.02.005
                    
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To build a method that Curcumin（Cur） of Curcumin novel nano emulsion，CNNE） were measured by HPLC，study the pharmacokinetic characteristics of the CNNE，and compare the bioequiavailability of CNNE and Cur. CNNE was prepared by water droplets method，and plasma drug concentrations of different time points were measured by HPLC after oral administration CNNE and Cur. The curve of AUC was drew by excel software，and the main pharmacokinetic parameters and bioequiavailability were calculated by DAS2.1.1 software. The parameters of compartmental model，AUC（0-∞） of CNNE and Cur，were（3 439.27±180.63）（μg·h）/L，（482.07±42.14）（μg·h）/L，and the parameters of compartmental model，AUC（0-∞） of CNNE and Cur，were（3 410.20±154.09）（μg·h）/L，（446.66±44.02）（μg·h）/L. The relative bioavailability of compartmental model and non-compartmental of CNNE are 713.44%，763.49%，respectively. The results show that prepared CNNE promoted absorption of Cur，and the bioavailability of CNNE is about seven times as much as Cur. CNNE and Cur are not bioequivalent.

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LEI Tingting, ZHANG Jingqing, ZHANG Xue, ZHANG Yanfang, ZHAO Hua. Study on Pharmacokinetics and Bioequivalence of Curcumin Novel Nano Emulsion in Rats[J]. Journal of Food Science and Biotechnology,2018,37(2):146-152.

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Online: April 03,2018
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