Analysis of the Content，Developmental Toxicity and Male Reproductive Toxicity of Nε-（Carboxymethyl） lysine in Instant Noodles

doi:10.3969/j.issn.1673-1689.2018.07.004

Home > Archive>Volume 37, Issue 7, 2018 >695-700. DOI:10.3969/j.issn.1673-1689.2018.07.004

Analysis of the Content，Developmental Toxicity and Male Reproductive Toxicity of Nε-（Carboxymethyl） lysine in Instant Noodles
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                        10.3969/j.issn.1673-1689.2018.07.004
                    
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Abstract:

Nε-（carboxymethyl） lysine（CML） concentrations in instant noodles of 20 brands were determinated using enzyme-linked immunosorbent assay（ELISA），then developmental and reproductive toxicity of CML were evaluated in vitro. Concentrations of CML in free form and bind form were 0.39~0.80 mg/kg and 19.42~34.99 mg/kg，respectively. No significant effect of CML was found on cell viability（CML≤1 mmol/L） and progesterone secretion（CML≤2 mmol/L） of R2C cells treated with CML for 24 h. Moreover，CML of concentration lower than 4 mmol/L has no significant effect on 3T3 cells treated with CML for 10 days，and CML of concentration lower than 0.5 mmol/L has no significant effect on D3 cells treated with CML for 10 days. According to the concentrations of CML detected in the present study，CML would not inhibit the progesterone secretion of R2C cells or cell viability of R2C，3T3，and D3 cells with regular intake of instant noodles. Thus，regular intake of instant noodles would not cause developmental or male reproductive toxicity induced by CML.

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SUN Jianxia, WEN Luona, ZHANG Zhenhua, ZHU Cuijuan, OU Shiyi, BAI Weibin. Analysis of the Content，Developmental Toxicity and Male Reproductive Toxicity of Nε-（Carboxymethyl） lysine in Instant Noodles[J]. Journal of Food Science and Biotechnology,2018,37(7):695-700.

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Online: September 28,2018
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