Preparation and Antitumor Activity of Doxorubicin-Loaded Hyaluronic Acid Modified Liposomes

doi:10.3969/j.issn.1673-1689.2018.12.007

Home > Archive>Volume 37, Issue 12, 2018 >1272-1277. DOI:10.3969/j.issn.1673-1689.2018.12.007

Preparation and Antitumor Activity of Doxorubicin-Loaded Hyaluronic Acid Modified Liposomes
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                        10.3969/j.issn.1673-1689.2018.12.007
                    
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Doxorubicin（DOX）-loaded hyaluronic acid（HA） modified Liposomes（DOX/LP/ HOA） were prepared to enhance receptor mediated endocytosis and improve anti-tumor effect. Octadecyl was chosen to conjugate HA backbone by amide bond to prepare hyaluronic acid-octodecane（HOA） polymers. DOX，as a model drug，was encapsulated into HOA modified liposomes by the film dispersion method and post-insertion method. The average particle size，zeta potential and encapsulation of DOX/LP/HOA were（50.17±0.60） nm，（-7.61±0.43） mV and（98.85±0.40）%，respectively. In vitro release and cytotoxicity results showed that DOX/LP/HOA could release DOX slowly and improve tumor targeting ability. DOX/LP/HOA with excellent anti-tumor activity can be used as the potential carrier for delivery of anti-tumor drugs.

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HUANG Yan, QIU Lipeng, ZHU Mengqin, SU Dandan, CHEN Jinghua. Preparation and Antitumor Activity of Doxorubicin-Loaded Hyaluronic Acid Modified Liposomes[J]. Journal of Food Science and Biotechnology,2018,37(12):1272-1277.

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Online: January 04,2019
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