Studies on the Hypoglycemic Activity of Lycium barbarum L. Water Extracts

doi:10.3969/j.issn.1673-1689.2019.03.013

Home > Archive>Volume 38, Issue 3, 2019 >91-96. DOI:10.3969/j.issn.1673-1689.2019.03.013

Studies on the Hypoglycemic Activity of  Lycium barbarum L. Water Extracts
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                        10.3969/j.issn.1673-1689.2019.03.013
                    
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Lycium barbarum L. plays roles in anti-aging，anti-fatigue，anti-fatty and immunity improvement. We used alloxan-induced diabetic mouse model to investigate hypoglycemic activity of Lycium Barbarum L. water extract（LBWE）. Metformin hydrochloride solution（Met） was served as positive drug. 28-day LBWE treatment significantly reduced mouse blood glucose compared to model group. LBWE strongly improved alloxan-induced weight loss，abnormal symptoms of food and water intake. The hypoglycemic activity of LBWE was further confirmed by the inhibition of serum glucose in glucose tolerance test. Moreover，LBEW-treated mice showed low MDA and high SOD and GSH-Px activity compared to model group，suggested that LBWE prevented oxidative stress associated with diabetes complications. In conclusion，LBWE has a hypoglycemic effect by preventing oxidative damage.

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HU Xinyu, LU Wenqian, SUN Xiaoqi, XU Hongkai, ZHANG Wei, ZHANG Shiqiang, KOU Ling. Studies on the Hypoglycemic Activity of Lycium barbarum L. Water Extracts[J]. Journal of Food Science and Biotechnology,2019,38(3):91-96.

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Online: June 21,2019
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