Anti-Inflammatory Activity of Mycelial Extracts from Armillaria mellea

doi:10.3969/j.issn.1673-1689.2019.03.020

Home > Archive>Volume 38, Issue 3, 2019 >138-143. DOI:10.3969/j.issn.1673-1689.2019.03.020

Anti-Inflammatory Activity of Mycelial Extracts from Armillaria mellea
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                        10.3969/j.issn.1673-1689.2019.03.020
                    
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Abstract:

Armillaria mellea is a well-known edible and medicinal mushroom，Whereas little information is available in regard to A. mellea's anti-inflammatory activity. In this study we explored the anti-inflammatory activity of n-hexane，chloroform，ethyl acetate and n-butyl alcohol extracts from Armillaria mellea. Our work will provide a scientific basis for screening new natural anti-inflammatory substances and a new medical application of Armillaria mellea. MTT colorimetric assay was applied to measure the cytotoxic effects of different extracts. Their anti-inflammatory activities were evaluated via inhibition against production of lipopolysaccharide（LPS）-induced nitric oxide（NO），tumor necrosis factor alpha（TNF-α），interleukin-6（IL-6） and interleukin-1beta（IL-1β） in murine macrophage-like cell line RAW264.7 cells. Cytotoxic assay showed that only n-hexane and chloroform extracts in a high concentration（300 μg/mL） have slight cytotoxic effects（inhibited 10.7% & 17% of cell viability） in RAW264.7 cells. As to the anti-inflammatory activity，except to the n-butyl alcohol extract，the other three extracts all can dose-dependently inhibited LPS-induced NO，TNF-α，IL-6 and IL-1β production. Among them，the ethyl acetate extract own both safty and anti-inflammatory activity.

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ZHU Shuiling, GENG Yan, CHENG Peng, LI Wang, LU Zhenming, GONG Jingsong, XU Hongyu, SHI Jingsong, XU Zhenghong. Anti-Inflammatory Activity of Mycelial Extracts from Armillaria mellea[J]. Journal of Food Science and Biotechnology,2019,38(3):138-143.

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Online: June 21,2019
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