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Home > Archive>Volume 38, Issue 7, 2019 >100-107. DOI:10.3969/j.issn.1673-1689.2019.07.014
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Effects of High-Fat Diet on the Bone of Obesity Prone and Obesity Resistant Mice and the Intervention of Quercetin
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    Abstract:

    To investigate the effects of high-fat diet（HFD） on the bone of obesity resistant（OR） and obesity prone（OP） mice and the intervention of quercetin. Mice were randomly divided into two groups：regular diet group（C） and HFD group. After 7 weeks，HFD-fed mice were devided into OP and OR group according to body weight and treated with quercetin. Femur parameters，redox status and expressions of osteoblast and osteoclast differentiation related genes were measured before and after quercetin treatment. The results showed that HFD treatment significantly decreased femur parameters of OP and OR mice. The expressions of osteoclast differentiation related genes were significantly up-regulated while the osteoblast differentiation related genes were down-regulated significantly in both OP and OR mice. Femur properties were improved after quercetin treatment. Consistent with the above mentioned，the content of MDA was higher，while the antioxidant indexes and the expression of antioxidant related genes were significantly lower in OP and OR mice. Redox status was improved after quercetin treatment. HFD treatment led to oxidative stress in femurs of OR and OP mice，may by affecting the expressions of osteoblast and osteoclast differentiation related genes，consequently reduced the femur properties. Quercetin can improve redox status，thereby improving femur properties of HFD-fed OP and OR mice.

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ZHOU Yinzhi, XIA Shufang, DUAN Xiaomei, YAN Biao, SHI Yonghui, LE Guowe. Effects of High-Fat Diet on the Bone of Obesity Prone and Obesity Resistant Mice and the Intervention of Quercetin[J]. Journal of Food Science and Biotechnology,2019,38(7):100-107.

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