Effects of Methionine Restriction on Bone of Mice Fed with High Fat Diet

doi:10.3969/j.issn.1673-1689.2019.08.013

Home > Archive>Volume 38, Issue 8, 2019 >91-96. DOI:10.3969/j.issn.1673-1689.2019.08.013

Effects of Methionine Restriction on Bone of Mice Fed with High Fat Diet
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                        10.3969/j.issn.1673-1689.2019.08.013
                    
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To investigate the effects of methionine restricted diet on the bone strength，redox state and femur microstructure of mice. 54 mice（C57BL/6） were randomly divided into normal control group（4% fat，0.86% methionine，CON），high-fat group（20% fat，0.86% methionine，HF），and high-fat with methionine restriction（MR） group（20% fat，0.17% methionine，MR）. After 11 and 22 weeks，the femur dry weight，femur length，bone mineral density，bone mineral content，bone strength of femur and redox state were determined，and the femoral micro-structures of 22 weeks mice were observed. Results showed that the weight of MR mice at 22 weeks was similar to that of CON group. Compared with HF group，the femur dry weight，femur length and bone mineral content in MR group decreased significantly at 11 weeks（P < 0.05），but increased to be similar to HF group and control group（P > 0.05） at 22 weeks，and the bone mineral content was significantly higher than HF group（P < 0.05），the trabecular thickness and cancellous bone volume increased significantly；although the bone strength of MR group was significantly lower than HF group，the bone strength/body weight at 11 and 22 weeks was higher than that of HF group（P < 0.05）. MR diet improved the redox state of the bones（P < 0.05），increased the content of bone mineral，increased the bone strength/body weight and enhanced the bone quality. Conclusion：Long-term MR diet could control body weight，could improve the femoral micro-structure and the bone quality.

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GUO Haitao, WANG Yanan, ZHANG Jiahong, SHI Yonghui, LE Guowei. Effects of Methionine Restriction on Bone of Mice Fed with High Fat Diet[J]. Journal of Food Science and Biotechnology,2019,38(8):91-96.

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Online: March 27,2020
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