Erythrocyte Membrane Biomimetic Boron Nitride Nanospheres as Carrier for the Delivery of Antitumor Drug

doi:10.3969/j.issn.1673-1689.2019.09.010

Home > Archive>Volume 38, Issue 9, 2019 >72-77. DOI:10.3969/j.issn.1673-1689.2019.09.010

Erythrocyte Membrane Biomimetic Boron Nitride Nanospheres as Carrier for the Delivery of Antitumor Drug
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                        10.3969/j.issn.1673-1689.2019.09.010
                    
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In this work，red blood cell（RBC） membrane coating technique was used to camouflage inorganic BNNS，thus forming biomimetic RBC-membrane-coated BNNS（RBC-BNNS） drug delivery system. The functionalization of BNNS with RBC-membrane was characterized by transmission electron microscopy（TEM），particle size and zeta potential analysis. Besides，the influence of RBC-membrane modification to the drug loading capacity was also analyzed with doxorubicin（DOX） as model drug. Then，the human cervical carcinoma cell line HeLa cells was selected as model cancer cells to investigate the biocompatibility of RBC-BNNS and the cellular uptake and antitumor effect of DOX@RBC-BNNS.

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FENG Shini, ZHANG Huijie, GAO Xiaodong, NAKANISHI Hideki. Erythrocyte Membrane Biomimetic Boron Nitride Nanospheres as Carrier for the Delivery of Antitumor Drug[J]. Journal of Food Science and Biotechnology,2019,38(9):72-77.

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Online: March 31,2020
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