Effect of Hericium erinaceus on Gut Microbiota in Mice with Colitis

doi:10.3969/j.issn.1673-1689.2019.09.014

Home > Archive>Volume 38, Issue 9, 2019 >97-102. DOI:10.3969/j.issn.1673-1689.2019.09.014

Effect of Hericium erinaceus on Gut Microbiota in Mice with Colitis
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                        10.3969/j.issn.1673-1689.2019.09.014
                    
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The study aimed to investigate the effect of Hericium erinaceus（HE） on intestinal microbiota of mice with colitis. C57BL/6 male mice were randomly divided into four groups （normal，model，HE low and high dose groups）. Mice were induced by 2% dextran sulfate sodium （DSS） to establish the mouse model of ulcerative colitis. Meanwhile，mice of high and low dose groups administrated dry powder of HE （250 mg/kg/d and 500 mg/kg/d） and drunk 2% DSS. After 7 days，disease activity index was scored and the shift of gut microbiota was examined by PCR-DGGE technology. The results showed that HE possesses anti-colitis activity. The administration of HE could significantly increase the body weight，decrease the score of disease activity index，and improve the histological change induced by DSS. Furthermore，HE restored the disordered gut microbiota caused by DSS and increased the proportions of Akkermansia muciniphila and Barnesiella intestinihominis. Therefore，the results demonstrated that HE possesses anti-colitis activity，partially through modulating gut microbiota.

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LI Wang, GENG Yan, REN Yilin, SHI Jinsong, XU Zhenghong. Effect of Hericium erinaceus on Gut Microbiota in Mice with Colitis[J]. Journal of Food Science and Biotechnology,2019,38(9):97-102.

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Online: March 31,2020
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