D-Mannose-Conjugated Micelles Loaded with Photosensitizers for Targeted Photodynamic Therapy

doi:10.3969/j.issn.1673-1689.2019.10.007

Home > Archive>Volume 38, Issue 10, 2019 >43-51. DOI:10.3969/j.issn.1673-1689.2019.10.007

D-Mannose-Conjugated Micelles Loaded with Photosensitizers for Targeted Photodynamic Therapy
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                        10.3969/j.issn.1673-1689.2019.10.007
                    
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In this paper，the D-mannose-modified amphiphilic β-cyclodextrin（C₃-CD-Man₇） and a three-arm adamantine-conjugated BODIPY photosensitizer（BTA） are synthesized. Because of the presence of supramolecular host-guest interactions between β-cyclodextrin and adamantane，BTA is loaded into the hydrophobic cavity of micelles self-assembled from C3-CD-Man₇，leading to the formation of BTA-loaded micelles（BTA@C₃-CD-Man₇）. The size，morphology，and stability of BTA@C₃-CD-Man₇are characterized by transmission electron microscopy and dynamic light scattering. The cellular uptake，PDT effect，and phototoxicity of BTA@C₃-CD-Man₇ are investigated using the MTT assay. The results show that BTA@C₃-CD-Man₇ has uniform size distribution and excellent stability in aqueous solution. More importantly，BTA@C₃-CD-Man₇ could be specifically internalized by MDA-MB-231 breast cancer cells that overexpress mannose receptors on cell surfaces. Thus，with 665 nm LED irradiation，the enhanced phototoxicity of BTA@C3-CD-Man7 showed their potential for targeted photodynamic therapy applications.

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CAI Ying, WANG Shengtao, WEI Peng, ZHANG Quan, YIN Jian. D-Mannose-Conjugated Micelles Loaded with Photosensitizers for Targeted Photodynamic Therapy[J]. Journal of Food Science and Biotechnology,2019,38(10):43-51.

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