Dityrosine Layer Endows Spores with Resistance to Oxidative Stresses

doi:10.3969/j.issn.1673-1689.2019.10.017

Home > Archive>Volume 38, Issue 10, 2019 >119-125. DOI:10.3969/j.issn.1673-1689.2019.10.017

Dityrosine Layer Endows Spores with Resistance to Oxidative Stresses
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                        10.3969/j.issn.1673-1689.2019.10.017
                    
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The spore wall of the budding yeast Saccharomyces cerevisiae has a multilaminar structure and its outermost layer，termed the dityrosine layer，is mainly composed of a phenolic compound，N，N′-bisformyl dityrosine. Since many cellular phenolic compounds are capable of scavenging free radicals，we hypothesized that N，N′--bisformyl dityrosine could work as an antioxidant. Thus，we investigated whether the dityrosine layer could protect cells from oxidative stresses and N，N′--bisformyl dityrosine have antioxidant activity. Yeast spores with or without the dityrosine layer were treated with reactive oxygen species and their sensitivities to the stresses were assessed. Additionally，N，N′--bisformyl dityrosine was produced by using vegetative cells and its antioxidant activity was measured. Compared to wild-type spores，idit1Δ spores，which lack the dityrosine layer，were sensitive to free radicals. Thus，the dityrosine layer can protect spores from oxidative stresses. Furthermore，we found that N，N′-bisformyl dityrosine can scavenge free radicals. The results suggest that N，N′--bisformyl dityrosine is an intriguing material as an antioxidant. N，N′-

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MUKAMA Omar, LEO Bemena, WANG Xiaowen, GAO Xiaodong, NAKANISHI Hideki. Dityrosine Layer Endows Spores with Resistance to Oxidative Stresses[J]. Journal of Food Science and Biotechnology,2019,38(10):119-125.

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