Abstract:Lipid is one of the three major nutrients needed by the human body, and its safety and health characteristics during the whole ingestion chain are highly valued. Pro-oxidation factors in the gastrointestinal tract, such as hydroxyl group, active nitrogen group, make lipids easy to generate oxidation reaction during gastrointestinal digestion. Compared with in vivo digestion evaluation, in vitro simulated digestion is the preferred method to study the gastrointestinal digestion of lipids since it is a timesaving method without ethical problems. At the same time, considering the complexity of human digestive tract environment and the diversity of lipids, the real evaluation of oxidation of lipids after digestion is particularly important. It is necessary to integrate and evaluate these methods to comprehensively explore the related problems when studying the process of digestion and oxidation of lipids in the digestive tract. The digestion process of lipids in vivo and the commonly used models of in vitro digestion of lipids were introduced. The detection methods of oxidation products during the digestion of lipids and the factors affecting the oxidation of lipids during digestion were described. It is very important to systematically study the oxidation mechanism and pathway of lipids during digestion.
