Protective Effects of the Active Fractions of Royal Jelly on the Aging Mice

doi:10.3969/j.issn.1673-1689.2022.07.012

Home > Archive>Volume 41, Issue 7, 2022 >130-139. DOI:10.3969/j.issn.1673-1689.2022.07.012

Protective Effects of the Active Fractions of Royal Jelly on the Aging Mice
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                        10.3969/j.issn.1673-1689.2022.07.012
                    
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This study explored the protective effects of royal jelly (RJ) and its major protein and lipid fractions on the D-galactose (D-gal) induced aging mice. In the experiment, the crude protein fractions, functional protein and lipid fractions were extracted and separated from royal jelly by dialysis, ultrafiltration and organic solvents, respectively. The aging mice model was established by intraperitoneal injection of 100 mg/kg D-gal per day for 7 weeks. The improved precision rate of mice in the T-maze and the reduction of liver organ index in mice intervened by royal jelly proved its beneficial functions on the aging-associated impairments of cognition and memory. Moreover, intervention of functional lipid fractions and functional protein fractions under high dose could significantly improve the accuracy of mice in T-maze and relief the liver enlargement. Therefore, both the functional protein and lipid fractions of royal jelly performed desirable anti-aging effects, and the mechanism may be related to the improvement of memory capacities.

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YU Xianxian, WANG Ling, LAN Tian, YU Chuntao, HUANG Wenqi, WU Quanyong, XIAO Qianhuang, NIE Xinke, TAN Huizi, NIE Shaoping. Protective Effects of the Active Fractions of Royal Jelly on the Aging Mice[J]. Journal of Food Science and Biotechnology,2022,41(7):130-139.

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Online: August 05,2022
Published: July 25,2022

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