Abstract:This study aimed to explore the therapeutic effect of iron-containing bovine blood peptide on iron-deficiency anemia (IDA) in rats, and to provide a theoretical basis for the development of functional products from bovine blood peptides. Early weaned female SD rats were fed with low-iron rat diet for 3 weeks to establish an iron-deficiency anemia model. Iron-containing rat diet was used as the normal control, and Shengxuening was used as the positive control. Rats were orally administered with the iron-containing bovine blood peptide until the level of haemoglobin exceeded 100 g/L. Changes in rat body weight and blood routine were monitored during the experiment. Iron-containing bovine blood peptide significantly improved the body weight and increased the hematological parameters such as leukocytes, red blood cells, hemoglobin, and hematocrit caused by iron-deficiency anemia in rats. At the meanwhile, it improved iron metabolism indicators, including serum iron and serum ferritin. The effects of low-dose bovine blood peptide were comparable to Shengxuening, while the medium-does and high-dose bovine blood peptide showed better effect than Shengxuening. Oral administration of iron-containing bovine blood peptide could effectively improve iron-deficiency anemia in rats.
