Abstract:Plant polyphenols are one of the most abundant antioxidants in human diets, which are involved in the regulation of body activity by interacting with cell signaling cascade and regulating the activity of transcription factors. In addition, polyphenols have been shown to influence microRNA (miRNA) expression. Moreover, miRNA can participate in most cell differentiation and homeostasis, playing an important role in many pathological. In recent years, advances in network-biology have fuelled our understanding of the regulatory networks controlled by multiple miRNA. In this paper, we have discussed the characteristics and mode of co-expressing miRNA in signal networks along with the complex and ordered relationship between miRNA and transcription factors. We also summarized the mechanism of action of single and multiple miRNA mediating plant polyphenols in regulating cardiovascular diseases, diabetes, inflammation and cancer, which is thought to help reveal more comprehensively and accurately the actual situation of plant polyphenols and other food nutrition and health factors in regulating physiological functions.
