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Home > Archive>Volume , Issue 1, 2025 >32-42. DOI:10.12441/spyswjs.20241230002
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Protective Effect of Pueraria thomsonii Benth Combined with Lactiplantibacillus plantarum Ali.Plateau.Lp.Ⅷ Against Acute Alcoholic Liver Injury in Mice
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1.College of Biological & Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China;2.Hubei Key Laboratory of Natural Products Research and Development, China Three Gorges University, Yichang 443002,China;3.College of Medicine and Health Sciences, China Three Gorges University, Yichang 443002, China;4.Angel Biotechnology Co., Ltd., Yichang 443003, China

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    Abstract:

    [Objective] The aim of the study is to investigate the effect of Pueraria thomsonii Benth combined with Lactiplantibacillus plantarum Ali. Plateau. Lp. Ⅷ (APLp. Ⅷ) on acute alcoholic liver injury in mice. [Method] A mouse model of acute alcoholic liver injury was established and treated by APLp. Ⅷ and/or Pueraria thomsonii Benth. The therapeutic effect on acute alcoholic liver injury was compared between the group with APLp. Ⅷ or Pueraria thomsonii Benth and the combination group. [Result] The mice in the combination group showed prolonged clinging and climbing time and an increased distance in the center in the open field test, which indicated that the combination enhanced the motor coordination and spatial exploration abilities of mice. Additionally, the blood of mice in the combination group showed a significant reduction in ethanol mass concentration and a significant increase in the activity of aldehyde dehydrogenase (ALDH). Furthermore, the combination group had significantly weakened activities of alanine aminotransferase (AST) and aspartate aminotransferase (ALT), a declined level of malondiadehyde (MDA), increased activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and enhanced total antioxidant capacity (T-AOC). Histopathological sections of the liver tissue showed significant alleviation of the injury in the combination group. [Conclusion] APLp. Ⅷ combined with Pueraria thomsonii Benth has synergistic effects in preventing alcoholic liver injury in mice.

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JIN Guoce, ZHENG Zejiang, WU Jiling, SUN Lian, ZUO Yifan, LI Xiao, TAN Yali, HUANG Rong, HE Haibo, ZOU Kun. Protective Effect of Pueraria thomsonii Benth Combined with Lactiplantibacillus plantarum Ali. Plateau. Lp.Ⅷ Against Acute Alcoholic Liver Injury in Mice[J]. Journal of Food Science and Biotechnology,2025,(1):32-42.

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History
  • Received:December 30,2024
  • Revised:February 21,2025
  • Adopted:
  • Online: May 12,2025
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