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Home > Archive>Volume 44, Issue 8, 2025 >49-60. DOI:10.12441/spyswjs.20250601001
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Bifidobacterium adolescentis FHNFQ5M4 Modulates Gut Microbiota and Alleviates Colitis in Mice
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1.Sinopharm Xingsha Pharmaceutical (Xiamen) Co., Ltd., Xiamen 361026, China;2.Xiamen Key Laboratory of Maternal and Infant Health and Nutrition Products, Xiamen 361026, China;3.School of Food Science and Technology, Jiangnan University, Wuxi 214122, China;4.The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214023, China;5.Wuxi Medical Center of Nanjing Medical University, Wuxi 214023, China

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    Abstract:

    [Objective] This study aims to verify and screen the Bifidobacterium adolescentis strains with vitamin A (VA) metabolic capacity, and investigate their effects on colitis symptoms and gut microbiota in mice. [Method] The VA metabolic capacity of a panel of Bifidobacterium adolescentis strains was evaluated through in vitro fermentation, and the strain with the highest VA metabolic capacity was ultimately selected. This strain was administered orally to mice with dextran sulfate sodium (DSS)-induced colitis for 6 consecutive days. After the intervention, histopathological changes in the colonic tissue were assessed, and the levels of intestinal injury markers in the serum and cytokines, antioxidant enzymes, and retinoic acid (RA) in the colonic tissue were measured. Additionally, gut microbiota composition was analyzed by metagenomic sequencing. [Result] Bifidobacterium adolescentis FHNFQ5M4 which possessed the highest VA metabolic capacity significantly alleviated the damage induced by DSS, modulated the cytokine and RA levels, and mitigated the oxidative stress in mouse colonic tissue. Moreover, Bifidobacterium adolescentis FHNFQ5M4 markedly altered the gut microbiota composition in colitis mice, leading to enrichment of Butyricimonas and reduced relative abundance of Staphylococcus. [Conclusion] Bifidobacterium adolescentis FHNFQ5M4 can effectively modulate the gut microbiota and alleviate DSS-induced colitis symptoms in mice, demonstrating the potential as a probiotic candidate for the treatment of ulcerative colitis (UC).

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WANG Yi, HUANG Liming, YU Xihua, LI Liuruolan, LU Wenwei, WANG Hongchao, ZHANG Zhijian.Bifidobacterium adolescentis FHNFQ5M4 Modulates Gut Microbiota and Alleviates Colitis in Mice[J]. Journal of Food Science and Biotechnology,2025,44(8):49-60.

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History
  • Received:June 01,2025
  • Revised:August 04,2025
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  • Online: November 26,2025
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